RETIN A

Reducing Skin Wrinkles with Retin A

INDICATIONS

This medication is used in the treatment of acne. It reduces the formation of pimples and promotes quick healing of pimples that do develop.

RETIN-A® MICRO ®(tretinoin gel) microsphere 0.1% is indicated for topical application in the treatment of acne vulgaris.

It is the first prescription product to use Advanced Polymer System's unique Microsponge® system. This technologically-advanced system is designed to minimize the irritation commonly experienced with the highest strength of RETIN-A® (tretinoin).

RETIN-A MICRO contains tretinoin, the same active ingredient as RETIN-A and RENOVA® (tretinoin cream) 0.05%. RETIN-A and RETIN-A MICRO are indicated for acne vulgaris, while RENOVA is indicated for fine wrinkles, brown spots and surface roughness when used as part of a comprehensive skin care program.

RETIN-A MICRO entraps tretinoin in Microsponge systems (round microscopic particles made of synthetic polymer). The microspheres hold the medication in reserve, allowing the skin to absorb small amounts of tretinoin over time. Dermatologists who conducted the pivotal clinical studies believe this may be why most RETIN-A MICRO patients experience little or no irritation. The microspheres themselves remain on top of the skin and are easily washed off when patients shower or wash their faces. Although its exact mode of action is unknown, tretinoin is thought to loosen and expel existing acne plugs under the skin and prevent new lesions from forming.

RETIN-A MICRO also reduces the appearance of facial shine (oiliness) on the skin's surface. Therapeutic results may be noticed after two weeks, but up to seven weeks of therapy may be required before consistent beneficial effects are observed.

RETIN-A MICRO significantly improved patients' acne by 12 weeks in clinical studies. In clinical studies, the RETIN-A MICRO irritation profile was found to be similar to a mild, local irritant. The most common adverse reactions to RETIN-A MICRO were limited to mild or moderate irritation of the skin. Severe cutaneous irritation occurred infrequently. Six percent of patients discontinued due to irritation. As with all topical retinoids, the skin of certain individuals may become excessively dry, red, swollen, or blistered.

Ortho Dermatological recommends application of RETIN-A MICRO once daily in the evening after washing. Like other prescription retinoid products, this product must also be used with caution in the sunlight, as it thins the stratum corneum (outermost layer of the skin), making the skin sensitive to sunlight. Follow basic sun protection guidelines, avoid extensive sun exposure, and if you have questions, please consult us.